NueCog 5-Amino-1MQ | Research-Grade NNMT Inhibitor, UK Formulated

NueCog formulates 5-Amino-1MQ for laboratory and in-vitro research applications, formulated and encapsulated in the UK to research-grade standards with independent third-party batch testing.

5-Amino-1MQ is a selective, membrane-permeable small molecule inhibitor of Nicotinamide N-Methyltransferase (NNMT) — an enzyme increasingly recognised for its role in metabolic regulation, adipogenesis, and cellular NAD⁺ homeostasis. Developed through research into obesity and metabolic disease, it has attracted significant scientific interest for its ability to modulate the methionine cycle and influence energy metabolism at the epigenetic level.

Why Researchers Choose NueCog 5-Amino-1MQ

  • •  Verified purity — ≥98% (HPLC verified), with a Certificate of Analysis available for every batch on request.
  • •  UK-formulated — formulated and encapsulated under controlled quality protocols, not relabelled or imported from unverified sources.
  • •  Consistent supply — the product researchers reorder is the same one they tested with previously.

Research Background

NNMT is highly expressed in adipose tissue and functions as a key regulator of the methyl economy within cells. Selective inhibition with 5-Amino-1MQ has been explored across a range of preclinical research contexts, including:

  • •  Adipocyte metabolism — reduction of fat cell size and lipid accumulation in in-vitro models.
  • •  NAD⁺ pathway modulation — restoration of SAM and NAD⁺ precursor availability via NNMT suppression.
  • •  Epigenetic regulation — influence on histone methylation patterns linked to metabolic gene expression.
  • •  Obesity and diet-induced metabolic dysfunction — preclinical models examining weight regulation and insulin sensitivity.
  • •  Cellular senescence — emerging research into NNMT's role in ageing-associated metabolic decline.

This section is for research and educational reference only. NueCog 5-Amino-1MQ is not intended for human consumption, veterinary use, diagnostic application, or any therapeutic use, and none of the above constitutes usage guidance.

Quality Assurance

Every batch of NueCog 5-Amino-1MQ undergoes third-party analytical testing. Certificate of Analysis (CoA) available on request. All products are manufactured to research-grade standards under strict quality control protocols.

Intended Use

This product is sold strictly for laboratory and in-vitro research purposes only. It is not intended for human consumption, veterinary use, or diagnostic application. Not for sale to minors. This product is not a medicine, food supplement, or drug.