GHK-Cu

GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide found endogenously in human plasma, saliva, and urine. First isolated in 1973 by Dr Loren Pickart, GHK-Cu has since become one of the most extensively researched peptides in regenerative biology, with a uniquely broad activity profile spanning wound repair, collagen synthesis, antioxidant defence, and gene expression modulation. Plasma concentrations of GHK decline significantly with age — from approximately 200ng/mL at age 20 to under 80ng/mL by age 60 — making it a compound of considerable interest in longevity and tissue maintenance research.

Product Specifications

Research Background

GHK-Cu operates through a remarkably diverse set of biological mechanisms. Its copper-chelating properties allow it to modulate redox activity, whilst its peptide backbone interacts with a wide range of growth factor receptors and gene regulatory networks. Genomic studies have demonstrated that GHK-Cu influences the expression of over 4,000 human genes — including many associated with tissue remodelling, inflammation resolution, and cellular repair. Key areas of active scientific investigation include:

• Collagen and extracellular matrix synthesis — stimulation of collagen I, III, and VI production alongside elastin and glycosaminoglycan synthesis in dermal fibroblast research models
• Wound healing and tissue repair — acceleration of wound closure, angiogenesis, and granulation tissue formation across skin, muscle, and connective tissue models
• Antioxidant and anti-inflammatory activity — upregulation of superoxide dismutase and other antioxidant enzymes; suppression of pro-inflammatory cytokine expression including TGF-β1 and TNF-α
• Gene expression modulation — broad influence on gene networks governing tissue remodelling, stem cell activation, DNA repair, and apoptosis regulation
• Neuroprotection research — preclinical models examining nerve regeneration, neurotrophic factor expression, and protection against oxidative neuronal damage
• Hair follicle biology — stimulation of follicle enlargement and proliferative activity in models of hair growth and follicle cycling
• Longevity and senescence research — investigation into GHK-Cu's capacity to reverse gene expression patterns associated with cellular ageing and tissue degeneration
• Pulmonary research — emerging investigation into fibrosis models and lung tissue repair via TGF-β pathway modulation

Quality Assurance

Every batch of NueCog GHK-Cu is manufactured to research-grade standards and undergoes rigorous third-party analytical testing including HPLC purity analysis and mass spectrometry confirmation to verify both peptide integrity and copper complexation. Certificate of Analysis (CoA) available on request.

Intended Use

This product is sold strictly for laboratory and in-vitro research purposes only. It is not intended for human consumption, veterinary use, or diagnostic application. Not for sale to minors. This product is not a medicine, food supplement, or drug.