KPV

KPV (Lys-Pro-Val) is a naturally occurring C-terminal tripeptide fragment of alpha-Melanocyte Stimulating Hormone (α-MSH), a peptide with well-established immunomodulatory and anti-inflammatory properties. KPV retains the core anti-inflammatory activity of its parent peptide whilst offering superior stability and a markedly simpler molecular structure. Its small size and favourable physicochemical profile have made it a subject of growing interest in gastrointestinal, dermatological, and systemic inflammation research.

Product Specifications

Research Background

KPV exerts its effects primarily through direct interaction with melanocortin receptors (MC1R, MC3R) and via intracellular inhibition of pro-inflammatory signalling cascades, including NF-κB pathway suppression. Its ability to penetrate epithelial barriers and act locally within mucosal tissue has positioned it as a particularly valuable tool in gut inflammation research. Key areas of active scientific investigation include:

• Inflammatory bowel disease models — reduction of colonic inflammation markers in preclinical models of ulcerative colitis and Crohn's-like disease, including downregulation of TNF-α, IL-6, and IL-1β
• Gut mucosal integrity — research into epithelial barrier function, tight junction preservation, and intestinal permeability under inflammatory challenge
• Melanocortin receptor signalling — investigation of MC1R and MC3R-mediated anti-inflammatory pathways in immune cell populations
• Dermatological inflammation — preclinical models examining wound healing, psoriasis, and atopic dermatitis via topical and systemic administration routes
• Systemic immunomodulation — broad suppression of pro-inflammatory cytokine cascades across multiple tissue types without immunosuppressive side effect profiles observed in conventional agents
• Oral bioavailability research — study of tripeptide stability under gastrointestinal conditions and transepithelial absorption kinetics

Quality Assurance

Every batch of NueCog KPV is manufactured using solid-phase peptide synthesis (SPPS) and undergoes rigorous third-party analytical testing including HPLC purity analysis and mass spectrometry confirmation. Certificate of Analysis (CoA) available on request.

Intended Use

This product is sold strictly for laboratory and in-vitro research purposes only. It is not intended for human consumption, veterinary use, or diagnostic application. Not for sale to minors. This product is not a medicine, food supplement, or drug.