5-AMINO-1MQ

5-Amino-1MQ is a selective, membrane-permeable small molecule inhibitor of Nicotinamide N-Methyltransferase (NNMT) — an enzyme increasingly recognised for its role in metabolic regulation, adipogenesis, and cellular NAD⁺ homeostasis. Developed through research into obesity and metabolic disease, 5-Amino-1MQ has attracted significant scientific interest for its ability to modulate the methionine cycle and influence energy metabolism at the epigenetic level.

Product Specifications

Research Background

NNMT is highly expressed in adipose tissue and functions as a key regulator of the methyl economy within cells. By consuming S-adenosylmethionine (SAM) to methylate nicotinamide, NNMT effectively limits NAD⁺ precursor availability and suppresses energy expenditure. Selective inhibition with 5-Amino-1MQ has been explored across a range of preclinical research contexts, including:

• Adipocyte metabolism — reduction of fat cell size and lipid accumulation in in-vitro models
• NAD⁺ pathway modulation — restoration of SAM and NAD⁺ precursor availability via NNMT suppression
• Epigenetic regulation — influence on histone methylation patterns linked to metabolic gene expression
• Obesity and diet-induced metabolic dysfunction — preclinical models examining weight regulation and insulin sensitivity
• Cellular senescence — emerging research into NNMT's role in ageing-associated metabolic decline

Quality Assurance

Every batch of NueCog 5-Amino-1MQ undergoes third-party analytical testing. Certificate of Analysis (CoA) available on request. All products are manufactured to research-grade standards under strict quality control protocols.

Intended Use

This product is sold strictly for laboratory and in-vitro research purposes only. It is not intended for human consumption, veterinary use, or diagnostic application. Not for sale to minors. This product is not a medicine, food supplement, or drug.