METHYLENE BLUE

Methylene Blue (3,7-bis(dimethylamino)phenothiazin-5-ium chloride) is one of the most extensively studied synthetic compounds in biomedical research, with a scientific record spanning over 130 years. As a redox-active phenothiazine dye, Methylene Blue is uniquely capable of cycling between its oxidised (blue) and reduced (leucomethylene blue, colourless) states — a property that underpins its broad utility as an electron carrier and mitochondrial research tool.

Product Specifications

Research Background

Methylene Blue is one of the few compounds with documented activity across mitochondrial, neurological, and antimicrobial research domains. Its electron-shuttling capacity allows it to interact directly with the mitochondrial electron transport chain, bypassing dysfunctional complexes and supporting ATP synthesis. Active areas of scientific investigation include:

• Mitochondrial function — acts as an alternative electron carrier between NADH and cytochrome c, supporting Complex IV activity and oxygen consumption
• Neuroprotection research — explored in models of Alzheimer's, Parkinson's, and traumatic brain injury for its ability to enhance mitochondrial resilience and reduce oxidative stress
• Cognitive and memory research — preclinical studies examining its influence on memory consolidation and cerebral metabolic rate
• Hormesis modelling — well-documented biphasic dose-response behaviour, making it a valuable tool in hormesis and dose-dependency research
• Antimicrobial and photodynamic applications — long-established use in antimicrobial research, including photodynamic inactivation of pathogens
• Cellular redox biology — widely used as a redox indicator and in studies of oxidative stress, ROS generation, and antioxidant defence systems

Quality Assurance

NueCog Methylene Blue is supplied at USP-grade purity. Every batch undergoes third-party analytical testing. Certificate of Analysis (CoA) available on request. All products are manufactured to research-grade standards under strict quality control protocols.

Intended Use

This product is sold strictly for laboratory and in-vitro research purposes only. It is not intended for human consumption, veterinary use, or diagnostic application. Not for sale to minors. This product is not a medicine, food supplement, or drug.